Cell biology: Gene amplification and drug resistance
نویسندگان
چکیده
منابع مشابه
Gene Amplification, Drug Resistance, and Cancer1
The finding that genetic alterations, i.e., mutations, can involve quantitative changes, as contrasted to the qualitative changes, in a genome was first made in Drosophila (88) and more recently has been examined extensively as a developmental process with ribosomal genes in amphibians (18; see Ref. 13 for review). The phenomenon of selective gene amplification in cultured mam malian cells was ...
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Experimental studies about Leishmania resistance to metal and antifolates have pointed out that gene amplification is one of the main mechanisms of drug detoxification. Amplified genes code for adenosine triphosphate-dependent transporters (multidrug resistance and P-glycoproteins P), enzymes involved in trypanothione pathway, particularly gamma glutamyl cysteine synthase, and others involved i...
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An increased number of copies of specific genes may offer an advantage to cells when they grow in restrictive conditions such as in the presence of toxic drugs, or in a tumor. Three mathematical models of gene amplification and deamplification are proposed to describe the kinetics of unstable phenotypes of cells with amplified genes. The models differ in details but all assume probabilistic mec...
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Drug-resistant tuberculosis is caused by transmission of resistant strains of Mycobacterium tuberculosis and by acquisition of resistance through inadequate treatment. We investigated the clinical and molecular features of the disease in 2 families after drug-resistant tuberculosis was identified in 2 children. The findings demonstrate the potential for resistance to be transmitted and amplifie...
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ژورنال
عنوان ژورنال: Nature
سال: 1984
ISSN: 0028-0836,1476-4687
DOI: 10.1038/307212a0